Domino tilings in dimension 3
    
    
      
  
  In dimension 2, a domino is a $2\times 1$ rectangle. Domino tilings of quadriculated regions have been extensively studied, with several deep and famous results.
The corresponding problems in dimension 3 (or higher) appear to be almost without exception much harder. In dimension 2, it is known, for instance, that for any quadriculated disk any two tilings can be joined by a finite sequence of flips: a flip consists in lifting two adjacent dominos and placing them back after a quarter turn rotation.